April 2011 – March 2012

Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile. Schlackow I, Walker AS, Dingle K, Griffiths D, Oakley S, Finney J, Vaughan A, Gill MJ, Crook DW, Peto TE, Wyllie DH. PLoS medicine. [2012;9(7):e1001279]

Clinical Clostridium difficile: clonality and pathogenicity locus diversity. Dingle KE, Griffiths D, Didelot X, Evans J, Vaughan A, Kachrimanidou M, Stoesser N, Jolley KA, Golubchik T, Harding RM, Peto TE, Fawley W, Walker AS, Wilcox M, Crook DW. [2011;6(5):e19993]

High confidence prediction of essential genes in Burkholderia cenocepacia. Juhas M, Stark M, von Mering C, Lumjiaktase P, Crook DW, Valvano MA, Eberl L. PloS one. [2012;7(6):e40064]

A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance. Eyre DW, Golubchik T, Gordon NC, Bowden R, Piazza P, Batty EM, Ip CL, Wilson DJ, Didelot X, O'Connor L, Lay R, Buck D, Kearns AM, Shaw A, Paul J, Wilcox MH, Donnelly PJ, Peto TE, Walker AS, Crook DW. BMJ open. [2012;2(3)]

Streptococcus pneumoniae serotype-2 childhood meningitis in Bangladesh: a newly recognized pneumococcal infection threat. Saha SK, Al Emran HM, Hossain B, Darmstadt GL, Saha S, Islam M, Chowdhury AI, Foster D, Naheed A, El Arifeen S, Baqui AH, Qazi SA, Luby SP, Breiman RF, Santosham M, Black RE, Crook DW, Pneumococcal Study Group. PloS one. [2012;7(3):e32134]

Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic database study in Oxfordshire 1999-2011. Schlackow I, Stoesser N, Walker AS, Crook DW, Peto TE, Wyllie DH, Infections in Oxfordshire Research Database Team. The Journal of antimicrobial chemotherapy. [2012 Jun;67(6):1514-24]

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease. Young BC, Golubchik T, Batty EM, Fung R, Larner-Svensson H, Votintseva AA, Miller RR, Godwin H, Knox K, Everitt RG, Iqbal Z, Rimmer AJ, Cule M, Ip CL, Didelot X, Harding RM, Donnelly P, Peto TE, Crook DW, Bowden R, Wilson DJ. Proceedings of the National Academy of Sciences of the United States of America. [2012 Mar 20;109(12):4550-5]

Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing. Walker AS, Eyre DW, Wyllie DH, Dingle KE, Harding RM, O'Connor L, Griffiths D, Vaughan A, Finney J, Wilcox MH, Crook DW, Peto TE. PLoS medicine. [2012 Feb;9(2):e1001172]

Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Cornely OA, Crook DW, Esposito R, Poirier A, Somero MS, Weiss K, Sears P, Gorbach S, OPT-80-004 Clinical Study Group. The Lancet infectious diseases. [2012 Apr;12(4):281-9]

Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event. Golubchik T, Brueggemann AB, Street T, Gertz RE Jr, Spencer CC, Ho T, Giannoulatou E, Link-Gelles R, Harding RM, Beall B, Peto TE, Moore MR, Donnelly P, Crook DW, Bowden R. Nature genetics. [2012 Jan 29;44(3):352-5]

Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitution. Lewis J, Walker AS, Castro H, De Rossi A, Gibb DM, Giaquinto C, Klein N, Callard R. The Journal of infectious diseases. [2012 Feb 15;205(4):548-56]

Clostridium difficile mixed infection and reinfection. Eyre DW, Walker AS, Griffiths D, Wilcox MH, Wyllie DH, Dingle KE, Crook DW, Peto TE. Journal of clinical microbiology. [2012 Jan;50(1):142-4]

Improved treatment outcomes with (18) F-FDG PET/CT for patients with advanced head and neck squamous cell carcinoma. Haerle SK, Soyka MB, Schmid DT, Ahmad N, Huber GF, Crook DW, Hany TF. Head & neck. [2012 Sep;34(9):1205-11]

Decline of meticillin-resistant Staphylococcus aureus in Oxfordshire hospitals is strain-specific and preceded infection-control intensification. Wyllie DH, Walker AS, Miller R, Moore C, Williamson SR, Schlackow I, Finney JM, O'Connor L, Peto TE, Crook DW. BMJ open. [2011 Aug 27;1(1):e000160]

Characteristics of CTX-M ESBL-producing Escherichia coli isolates from the Lao People's Democratic Republic, 2004-09. Stoesser N, Crook DW, Moore CE, Phetsouvanh R, Chansamouth V, Newton PN, Jones N. The Journal of antimicrobial chemotherapy. [2012 Jan;67(1):240-2]

Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection. Stoesser N, Crook DW, Fung R, Griffiths D, Harding RM, Kachrimanidou M, Keshav S, Peto TE, Vaughan A, Walker AS, Dingle KE. Journal of clinical microbiology. [2011 Nov;49(11):3994-6]

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. Ibarz-Pavon AB, Maclennan J, Andrews NJ, Gray SJ, Urwin R, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala'aldeen D, Crook DW, Cann K, Harrison S, Cunningham R, Baxter D, Kaczmarski E, McCarthy ND, Jolley KA, Cameron JC, Stuart JM, Maiden MC. The Journal of infectious diseases. [2011 Oct 1;204(7):1046-53]